Renal Denervation Devices a Potential Therapeutic Option for Patients with Resistant Hypertension


Renal denervation (RDN) devices are medical devices used in minimally invasive procedures to treat resistant hypertension. It is a safe and effective procedure for people with treatment‐resistant hypertension with a clinically significant antihypertensive effect. A procedure uses radiofrequency ablation to burn the nerves in the renal arteries. Renal denervation causes a reduction in the nerve activity, which decreases blood pressure. This minimally invasive procedure removes nerves from the renal artery (which leads to the kidneys).

RDN can reduce/eliminate need for blood pressure medication. Renal denervation ablates afferent and efferent sympathetic nerves in the adventitia of renal arteries. Renal denervation devices are inserted percutaneously into the femoral artery and advanced into the main renal arteries under the fluoroscopic guidance. Several renal denervation devices exist commercially, such as Iberis renal sympathetic denervation system, paradise renal denervation system, EnligHTN renal denervation system, Vessix renal denervation system, simplicity renal denervation system, and more.

The global Renal Denervation Devices Market size was valued at US$ 88.6 million in 2017, and is expected to exhibit a CAGR of 35.5% over the forecast period (2018 – 2026).

Renal denervation is catheter-based procedure used to treat resistant hypertension (blood pressure not controlled by drug), using ultrasound ablation or radiofrequency ablation. Renal denervation therapy (RDT) is a relatively new, catheterization-based intervention to treat people with refractory hypertension. The rationale of RDT is the mechanical destruction with high frequency ablation of renal sympathetic fibers, which can be easily accessed via the renal artery. RDN has emerged as a potential therapeutic option for patients with resistant hypertension.

Thus, with the increase in prevalence of hypertension, the use of Renal Denervation Devices is also increasing rapidly across the world. Prevalence of resistant hypertension is high in a secondary-care practice in Asia Pacific (APAC), especially in India. Currently, no renal denervation device is approved in the United States, which limits the treatment to investigational use. However, the procedure is available in several other countries. Medtronic and ReCor Medical have competing devices that are approved for use in Europe.


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